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Pfaffenhofen is a municipality in the district of Heilbronn in Baden-Württemberg in Germany.
Pfaffenhofen was presumably founded in times of the Christianization of Germany. It was first mentioned documentary as Pfaffenhoven on May 30, 1279. Already before 1380 Burkhard von Hohenberg sold the half of the village to Württemberg, in 1380 the other half followed.
Weiler an der Zaber presumably already existed around 1000. It was first mentioned documentary on June 15, 1279. In the 14th century the village came to Württemberg. On January 1, 1972, Weiler an der Zaber was incorporated to Pfaffenhofen.